Struggling AshantiGold will be looking to upset an in-form Hearts of Oak side who have opened a seven-point lead at the top of the Glo Premier League standings as they take on the Phobians on Wednesday.
The match-day-10 fixture pairs the Miners with the league leaders who enhanced their title aspirations on Sunday after beating champions, Asante Kotoko in Kumasi.
AshantiGold are caught up in the relegation zone as they sit a place above the bottom side with 15 points separating them and their mid-week opponents at the Ohene Djan Stadium, Hearts of Oak.
Asante Kotoko, still perturbed over Sunday's defeat and the departure of Belgian coach, Maurice Cooreman will have to pick up the pieces as Isaac Opeele Boateng leads them to play his former side, Tema Youth at the Tema Sports Stadium.
Another big game comes up at the Golden City Park as the local derby pairs Arsenals and Chelsea.
At the Swedru Park, bottom side, Gamba All Blacks take on Liberty Professionals while Kessben FC welcome Sporting Mirren to the Anane Boateng Stadium.
King Faisal will be at home to Sekondi Hasaacas at the Baba Yara Stadium.
Real Tamale United after their big win over the weekend will hope to maintain their winning form when they travel to Sekondi to play Eleven Wise.
Heart of Lions, playing at the Kpando Park will battle it out with Wa All Stars.