Hearts of Oak have to beat Sekondi Hasaacas at the Ohene Djan Stadium on Sunday to preserve their four point lead at the top after their midweek blip.
The Phobians slipped 1-2 at Tema Youth on Wednesday and a further slide will give challengers Heart of Lions and Asante Kotoko.
Hasaacas are 11th on the league table, one point above the drop zone on goal difference.
Bottom-placed AshantiGold seek to overturn their impressive run at home to 13th-placed Liberty Professionals at the Len Clay.
King Faisal entertain Sporting Mirren at the Baba Yara Stadium after their midweek away win over Liberty.
Third-bottom Gamba All Blacks host Chelsea of Bechem at the Swedru Park. Kessben FC play All Stars at Abrankese.
Real Tamale United will be seeking to make amends after a 1-3 home defeat to Heart of Lions when they at Berekum against Arsenals.
The Eleven Wise-Tema Youth and Heart of Lions- Kotoko fixtures have been postponed to 25 March.
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