The Black Stars of Ghana will host the Bafana Bafana of South Africa on Thursday, 14 November 2019 in Accra after CAF changed the initial dates for the Cameroon AFCON 2021 qualifiers.
Initially, Ghana was pencilled to play South Africa on 15 November.
Ghana are in Group C together with South Africa, Sudan and Sao Tome Principe.
Two teams from the Group will qualify for AFCON 2021 in Cameroon.
Sao Tome earned a historic victory over Mauritius – winning 3-1 in the first leg of the preliminary stage and followed it up with a 2-1 victory in the second leg to complete a remarkable 5-2 overall aggregate win.
Ghana will be hoping to win Africa's prestigious tournament after their abysmal display at the 2019 Africa Cup of Nations in Egypt.