Madrid-based Airline, Iberia, is set to begin scheduled flight from Accra to Madrid from July this year.
The airline will however start its operations in partnership with British Airways which merged with Iberia in 2010.
Ghana's commercial manager for British Airways James Wooldridge told Joy Business they will offer seamless travelling experience to their passengers.
He added that Iberia hopes to capitalize on the structures of British Airways to reduce their cost of operations
About 40 airlines could be operating from the Kotoka International Airport by the close of this year as four international airlines are due to start operations.
They include: China Eastern Airlines, Qatar Airways, Air Canada and Royal Jordanian Airlines