Head coach of the Ghana Black Stars, Coach Kwesi Appiah has named 23 man squad for the doubleheader in the 2021 Africa Cup of Nations qualifiers.
Ghana will host South Africa at the Cape Coast Stadium on November 14 before playing Sao Tomé & Príncipe.
The likes of Asamoah Gyan, John Boye, Kwadwo Asamoah and Christian Atsu have all be dropped from the 23 man squad.
However, seven players have handed a maiden call up for the clash.
They are Salisu Mohammed, Iddrisu Baba, Torric Jibril, Christopher Antwi-Adjei, Nicholas Opoku, Mohammed Kudus and Shafiu Mumuni.
Below is the full squad... GOALKEEPERS: Richard Ofori (Maritzburg FC, South Africa), Felix Annan (Asante Kotoko, Ghana), Razak Abalora (Azam FC, Tanzania)
DEFENDERS: Andy Yiadom (Reading, England), Harrison Afful (Columbus Crew, USA), Lumor Agbenyenu (Real Mallorca, Spain), Joseph Aidoo (Celta Vigo, Spain), Joseph Aidoo (Celta Vigo, Spain), Kassim Nuhu (Fortuna Dusseldorf, Germany), Nicholas Opoku (Udinese, Italy), Mohammed Salisu (Real Valladolid, Spain)
MIDFIELDERS: Samuel Owusu (Al Fahya, Saudi Arabia), Thomas Partey (Atletico Madrid, Spain), Alfred Duncan (Sassuolo, Italy), Mubarak Wakaso (Deportivo Alaves, Spain), Iddrisu Baba (Real Mallorca, Spain), Christopher Antwi-Adjei (SC Paderborn, Germany)
FORWARD: Andre Ayew (Swansea, England), Mohammed Kudus (FC Nordsjaelland, Denmark), Emmanuel Boateng (Dalian Yifang, China), Jordan Ayew (Crystal Palace, England), Torric Jibril (TP Mazembe, DR Congo), Shafiu Mumuni (Ashantigold)