The two biggest clubs in Ghana Football; Hearts and Kotoko, face difficult trips up north in the weekend's pairings of the Glo Premier League.
Real Tamale United in fourth, host third-placed Hearts of Oak at the Tamale Stadium with a win for the latter likely to propel them to the summit of the table.
Kumasi Asante Kotoko travel to Wa as guests of All Stars in an attempt to reverse recent unimpressive results.
Liberty Professionals entertain leaders Heart of Lions at the Ohene Djan Stadium in the late kick-off.
AshantiGold face stiff opposition in Kessben FC to record their second win of the season at the Len Clay.
King Faisal welcome Gamba All Blacks at the Baba Yara Stadium and Sekondi Hasaacas host Berekum Arsenals at the Essipong Stadium.
In Sunyani, new entrants Chelsea play plucky Tema Youth at the Coronation Park.
Sporting Mirren and Sekondi Eleven Wise battle on Monday night.
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