Visiting Coton Sport of Cameroun held Ghana's sole Champions League representatives Berekum Chelsea to a goalless game at the Golden City Park in Berekum.
Not even the fanatic home crowd of Chelsea intimidated the well-built Camerounians whose game plan worked to perfection.
Several goal-scoring opportunities came the way of the Ghanaians, but the clearest presented itself to striker Emmanuel Clottey but impatience robbed him of putting his side in front.
Chelsea, after qualifying at the expense of North African giants Raja Casablanca of Morocco, will travel to Cameroun for the return encounter.
The winner of the second leg will progress to the Money Zone of this year's CAF Champions League.
Chelsea coach Hans Vander Plume, in a post-match interview, blamed the loss on ill luck, but expressed the hope to qualify to the next stage.
By Kofi Owusu Aduonum