Hearts of Oak have been drawn against Division One side, Starke FC in the fourth round of the MTN FA Cup after avoiding the top sides.
Tuesday's live drawn handed the Phobians a home fixture against the first-tier campaigners.
Medeama and Berekum Chelsea aside their chase for the Premier League title will battle it out for another Cup as both sides draw each other in the Round of 16 pairing.
Asante Kotoko could play Rainbow FC if they edge Agbozume Weavers in the outstanding Round of 32 match.
No match will travel into extra-time as penalties will be used to determine the outcome in the event that a game ends in a draw after regulation time.
Round of 16 draw
Amidaus Professionals vrs Guan United
Weavers/Kotoko vrs Rainbow FC
Eleven Wise vrs Nania FC
Medeama vrs Berekum Chelsea
Hearts of Oak vrs Starke FC
Heart of Lions vrs Tudu Mighty Jets
Tema Youth vrs Aduana Stars
Gold Stars vrs AshantiGold
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