Liberty Professionals, fresh from their midweek heavy win over Hasaacas, are brimming with confidence of halting an improved Hearts of Oak side on Sunday in Accra.
Liberty thumped Hasmal 4-1 in Dansoman and defending champions Hearts drew goalless with RTU in Tamale.
Kessben FC must avoid a second defeat in a row at the Kpando against Heart of Lions, who made a winning start to the second half of the season.
Asante Kotoko's accent will come on test on the road when they engage Wa All Stars which lie two points behind the league leaders in third place.
Chelsea of Bechem will attempt to pick their first win in the second round against Great Olympics at the Coronation Park.
Leaders Aduana Stars are likely to retain their slot against relegation battlers Eleven Wise at the Dormaa Ahenkro Park.
There is a local derby in Obuasi where New Edubiase host AshantiGold at the Len Clay Stadium.
King Faisal's quest to beat the drop continues against Real Tamale United at the Baba Yara Stadium.
Sekondi Hasaacas revert to the Gyanadu Park to save their ailing league campaign against Berekum Arsenals.
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