The qualifying rounds of the 2007 Champions League were announced at Caf headquarters in Cairo on Thursday.
African champions Ahly from Egypt have a bye to the next round, where they are scheduled to meet either Highlanders of Zimbabwe or Pamplemousse of Mauritius.
Tunisia's Etoile du Sahel, who won this year's Confederation Cup, have also been exempted from first round action.
Asec Mimosas from the Ivory Coast and Morrocco's FAR Rabat are the other two clubs to receive a bye.
First Round Fixtures:
Highlanders (Zimbabwe) v Pamplemousse SC (Mauritius)
Sundowns (South Africa) v Royal Leopards (Swaziland)
St Pierroise (Reunion) v Desportivo Maputo (Mozambique)
Zamalek (Egypt) v Vital'O (Burundi)
Al Hilal (Sudan) v Polisi SC (Zanzibar)
Asante Kotoko (Ghana) v Gambia Ports Authority (Gambia)
ASFA Yennenga (Burkina Faso) v Nasarawa United (Nigeria)
Fello Star Labe (Guinea) v Sporting Praia (Cape Verde Islands)
Diaraf Dakar (Senegal) v Maranatha Fiokpo (Togo)
FC St Eloi Lupopo (DR Congo) v APR FC (Rwanda)
USM Alger (Algeria) v AS FNIS (Niger)
Al Ittihad (Libya) v Mogas '90 (Benin)
Canon Yaounde (Cameroon) v Etoile du Congo (Congo)
St George (Ethiopia) v ESCOM (Malawi)
Wydad Casablanca (Morocco) v ASC Mauritel (Mauritania)
Stade Malien (Mali) v AS Douanes (Senegal)
Ocean Boys (Nigeria) v FC Kallon (Sierra Leone)
Petro Atlético (Angola) v Civics (Namibia)
Young Africans (Tanzania) v AGSM (Comoros Islands)
Likhopo (Lesotho) v ZANACO (Zambia)
Esperance (Tunisia) v Renaissance (Chad)
Renacimiento (Equatorial Guinea) v AshantiGold (Ghana)
TP Mazembe Englebert (DR Congo) v Police XI (Botswana)
AS Adema (Madagascar) v Anse Reunion (Seychelles)
JS Kabylie (Algeria) v OS Balantas (Guinea Bissau)
Primeiro Agosto (Angola) v Mangasport (Gabon)
Coton Sport (Cameroon) v Revenue Authority (Uganda)
Sewe Sport (Ivory Coast) v Mighty Barolle (Liberia)
Teams mentioned first play at home in the first legs on the weekend of January 26-28. The return legs will be played on the weekend of February 9-11.