Napoli were frustrated for 70 minutes against 10 men and saw a penalty saved, but eventually swept Milan aside.
The Azzurri now move just four points away from third-placed Lazio and five from Roma. Both sides suffered humiliating defeats midweek, the Partenopei falling 4-2 at Empoli and Rossoneri beaten 3-1 at home by Genoa.
Rafa Benitez had the chance to close on the top three, but also rested some players for the Europa League semi-final against Dnipro.
Milan had Jeremy Menez, Philippe Mexes and Ignazio Abate suspended, plus Suso, Adil Rami, Luca Antonelli, Stephan El Shaarawy, Riccardo Montolivo and Michael Essien injured.
Milan have won here just twice in 19 years, both 2-1 results in January 1998 and October 2010.
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