The 21-year-old was signed by Ian Holloway in July last year ahead of Palace's first season back in the top flight.
He then went on to make six appearances during his time at Selhurst Park but fell out of favour under Holloway's successor Tony Pulis.
In January he was loaned out to Nuremberg in the Bundesliga where he suffered relegation.
Having made 10 appearances in the German top flight, Campana will move to Sampdoria for an undisclosed fee.
The former Sevilla man has represented Spain at various youth levels and will be tasked with helping to improve on Sampdoria's 12th-place finish last season.
2024 elections: Resign if you can't be faithful to party - Sagnarigu NDC PC desc...
Five arrested, remanded over alleged murder of two police officers at Transacco
Tax exemptions better than incentives for churches – Tax Analyst tell Bawumia
Transport Minister sues Law Platform Editor for defamation
Voter registration: Police arrest NPP Treasurer for Mpohor for registering minor
"This nonsense must stop" — Lawrence Tetteh vows to march to Jubilee House over ...
2024 elections: “If indeed you stand for peaceful elections the time is now for ...
I have the attributes to be president of this country — Bernard Monarh
Cecilia Dapaah saga: ‘Turf war’ between AG, EOCO, OSP indicates they’re not ‘cor...
Ghana will become the first African country to embrace blockchain-powered gover...
