Coach Kwesi Appiah has labelled Ghana's potential meeting with sworn-rivals Nigeria in the round of 16 at the 2019 Africa Cup of Nations.
The Black Stars face Guinea-Bissau on Tuesday needing a win to qualify from the group stage.
If Ghana win and Cameroon beat Benin, the Black Stars will finish second in Group F and will face Nigeria, who finished behind Madagascar in Group B, in the last 16.
"Nigeria are our brothers and anytime we meet them it is like a World Cup match but I am hopeful that once we qualify, we will beat any team in the last 16,” Appiah said.
Ghana's final group game against Guinea Bissau has been scheduled to kick off 16:00GMT.
Black Stars haven't won the tournament since 1982.