Naby Keita has been ruled out for two months with an abductor injury, meaning he will likely miss the African Cup of Nations in June.
Guinea international Keita picked up the injury in Liverpool's 3-0 loss at Barcelona on Wednesday.
"It was really unlucky. Bad news. High-grade abductor injury. The tendon is ruptured," said Liverpool manager Jurgen Klopp.
"It will keep him out for at least two months. Bad news for us and for Guinea with the Africa Cup of Nations coming up. Not nice," he said.
Liverpool travel to Newcastle United on Saturday as they trail Premier League leaders Manchester City by a point with two games remaining.