Guardiola's men were beaten 2-0 at Stamford Bridge, leaving Liverpool as the only unbeaten side in the league.
With only one game remaining, round 16 of the Premier League is all but done and dusted. All but one of this matchweek's games were played over the weekend, with the highlight fixture being Chelsea vs Man City.
And that Stamford Bridge game did not disappoint, as Sarri's men impressed en route to a 2-0 win over the reigning champion.
This means Liverpool is the only unbeaten team so far, having marched to a 4-0 win over Bournemouth.
Klopp's side now leads in the standings
Premier League
POS. TEAM MP W D L GF GA GD P FORM
1 Liverpool 16 13 3 0 34 6 +28 42 WWWWW
2 Manchester City 16 13 2 1 45 9 +36 41 LWWWW
3 Tottenham Hotspur 16 12 0 4 30 16 +14 36 WWLWW
4 Chelsea 16 10 4 2 33 13 +20 34 WLWLD
5 Arsenal 16 10 4 2 35 20 +15 34 WDWWD
6 Manchester United 16 7 5 4 28 26 +2 26 WDDDL
7 Everton 15 6 5 4 21 17 +4 23 DLWDW
8 AFC Bournemouth 16 7 2 7 25 26 -1 23 LWLLL
9 Leicester City 16 6 4 6 21 20 +1 22 LDWDD
10 Wolverhampton Wanderers 16 6 4 6 17 19 -2 22 WWLLD
11 West Ham United 16 6 3 7 23 25 -2 21 WWWLD
12 Brighton & Hove Albion 16 6 3 7 19 22 -3 21 LWWDL
13 Watford 15 6 2 7 18 21 -3 20 LLLDL
14 Cardiff City 16 4 2 10 15 30 -15 14 WLWLW
15 Newcastle United 16 3 4 9 13 22 -9 13 LDLWW
16 Crystal Palace 16 3 3 10 13 23 -10 12 LLWDL
17 Burnley 16 3 3 10 15 32 -17 12 WLLLD
18 Huddersfield Town 16 2 4 10 10 27 -17 10 LLLWD
19 Southampton 16 1 6 9 13 30 -17 9 LLDLD
20 Fulham 16 2 3 11 16 40 -24 9 LDLWL
Champions League (Group Stage)
Europa League (Group Stage)
Relegation - Championship
Elsewhere, Tottenham, Man United, and Arsenal all enjoyed wins. Here are the standout stats from the weekend action.
Guardiola's Man City is no longer unbeaten
Man City's unbeaten run is no longer. The reigning champion suffered their first defeat of the season, losing 2-0 at Stamford Bridge on Saturday.
This is the team's ninth defeat since Guardiola has taken over, and while nine losses may not be a bad record, the numbers highlight the Spaniard's struggles against Chelsea. They are his worst opponent in the English top-flight.
Arsenal leave it late... once again
Arsenal's clash with Huddersfield saw the least number of shots on target in a Premier League game since October 28, 2017.
Unai Emery's men got the job done, nonetheless, with Torreira scoring a late beauty to earn all three points.
This means no team has won more points in the last 10 minutes in the English top-flight this season than the Gunners.
Juan Mata reaches feat in 4-1 Fulham win
On Saturday, Man United marched to a 4-1 win over Fulham, with Juan Mata scoring a goal and setting up another in that victory.
This saw the diminutive midfielder join two Premier League stars as the only Spaniards to have 50+ goals and 50+ assists under his belt in the English top-flight.
Salah steals the show but it was a memorable game for Milner
In the 4-0 win over Bournemouth, Salah bagged a hat-trick to propel him to the top of the Golden Boot race.
However, it was a memorable game for James Milner, as he became the second-youngest player to make 500 appearances in the Premier League thanks to that game.
Tottenham's record start to the season continues
Tottenham traveled to Leicester over the weekend and earned a 2-0 victory. This result means their record start to the season keeps getting better.