Antony Watson to make first start for England against South Africa
The Bath wing comes in for his club team-mate, who made his debut in last weekend's 24-21 defeat to New Zealand, but was ruled out of the meeting with South Africa due to a hip problem.
Watson came off the bench in the loss to the world champions and his inclusion represents the only change to the starting XV for Stuart Lancaster's side.
The 20-year-old's place among the substitutes is taken by Harlequins' Marland Yarde.
"Anthony has been pushing hard for a while and has been in impressive form for Bath and in training with us," Lancaster said.
"It was great that he got on against New Zealand and we feel he is ready to start. Equally, it's good to have Marland back in the matchday 23.
"Congratulations to Danny Care who will be winning his 50th cap. It'll be a special moment for him and I am sure he will rise to the occasion.
"I know the players are looking forward to the challenge. South Africa have quality and experience across the park and it will be a big test for us."