Philipp Kohlschreiber sets up Novak Djokovic date in Paris
Kohlschreiber advanced past local hope Edouard Roger-Vasselin 6-3 6-1 at the hard-court ATP 1000 event in Paris, to book his seventh career meeting with Djokovic - the seven-time major winner holding a 5-1 head-to-head record.
The German has suffered defeat at the hands of Serbia's Djokovic at the clay-court Masters event in Rome, before a fourth-round loss to the eventual semi-finalist at the US Open.
Djokovic will be appearing for the first time on the ATP World Tour since becoming a father to son Stefan on Tuesday.
Austrian rising star Dominic Thiem set up a clash with third-seeded Swiss Stan Wawrinka, after downing Ukraine's Alexandr Dolgopolov.
Thiem beat Dolgopolov 6-2 4-6 6-0 and will face Wawrinka - who is out of form with four straight losses on tour - for the first time in his career.
American qualifier Jack Sock set up an all-North American battle with seventh-seeded Canadian Milos Raonic, after thrashing Spaniard Pablo Andujar 6-1 6-1.
Sam Querrey, also a qualifier from the US, got past Poland's Jerzy Janowicz 6-7 (5-7) 6-2 6-4 - recovering from double-faulting on set point in the opener to win through.
Julien Benneteau progressed at his home event, the Frenchman downing Taipei's Lu Yen-Hsun 6-3 6-4 and will next meet in-form Briton Andy Murray.
Richard Gasquet also advanced in more good news for the home fans, as the beneficiary of Denis Istomin's retirement - the Uzbek calling it quits when trailing 6-7 (4-7) 6-2 4-0.
Left-hander Adrian Mannarino won an all-wildcard battle against fellow Frenchman Pierre-Hugues Herbert 7-6 (7-3) 6-3.
Other left-handers to advance included Austria's Jurgen Melzer, a 6-4 6-1 winner over Spaniard Guillermo Garcia-Lopez, and Fernando Verdasco - who fought back to beat fellow lefty American Donald Young 4-6 6-1 6-3.
Colombia's Santiago Giraldo caused an upset, progressing past Russia's Mikhail Youzhny 6-2 6-4.