All four of Ghana's representatives in this year's continental series go into action this weekend.
Continental champions in 2000, Hearts of Oak, play their first leg game on home soil, while the three others, Asante Kotoko, King Faisal and Liberty Professionals, leave home for their respective games.
Champion Club, Kotoko, travel to Abidjan to play as guests to Ivorian champions Asec Mimosa, while Hearts of Oak welcome AS Aviacao of Angola to Accra in the Champions League competition.
King Faisal and Liberty Professionals also trek to Harare in Zimbabwe and the Angolan capital, Luanda, to play Power Dynamo and Petro Huambo respectively in the Confederations Cup.
Kotoko and Asec rekindle their rivalry in an interesting fixture in Abidjan. The Ivorians proved Kotoko's nemesis in the 1990s when the Ghanaian champions were cruising to continental glory.
In Accra, Hearts are faced with the challenge of another of their conquerors. Aviacao kicked the Ghanaian side out of the same competition last year with a 3-2 aggregate score and Hearts are presented with a chance to repeat the revenge achieved over Stade Malien at the first round stage.
Both Faisal and Liberty are making their debuts on the continental stage. Faisal, guests of Dynamo, were expected to leave last night with Coach Herbert Addo heading their technical bench, while Liberty make their adventure to Angola on the wings of a young team seeking a rare international experience.