Hearts of Oak must make sure their seven-point gap at the summit of the Glo Premier League stays intact when they host Liberty Professionals in the Accra derby on Sunday.
The Phobians have picked four points from their last three games, a statistic which shows a gradual dip in results judging by their imperious form before the last three matches.
Liberty Professionals on the other hand appear to be grinding results in their last two matches and could be a threat to the leaders' hopes of possibly widening the gap or maintaining the seven-point lead.
Bashiru Hayford would be out at the Anane Boateng Park to prove a point to Asante Kotoko when he guides Kessben FC against his former employers, a side he led to last season's championship.
Kotoko with a game in hand would be desirous of winning the tie to keep the pressure at the top of the table despite an eight-point difference between them and the leaders.
Fresh from boosting their battle against relegation, AshantiGold would have the duty of continuing with their fine midweek form when they host Chelsea at the Len Clay Stadium in Obuasi.
The Miners are now a step above the bottom side and can make it their second successive win which would be their first time producing a winning run this season.
Arsenals' three-year home invincibility is yet to be broken as the Berekum-side take on Tema Youth at the Golden City Park.
King Faisal would be at home to All Stars at the Baba Yara Stadium in Kumasi. Both sides ended their midweek matches in draws and would continue to push for top four places.
Second-placed Heart of Lions with a game in hand would be at the Kpando Park where they host Eleven Wise.
Gamba All Blacks after securing a late draw in midweek return from Wa to play Real Tamale United at the Swedru Sports Stadium.
The final fixture would see bottom placed, Sporting Mirren playing away to Hasaacas at the Sekondi Sports Stadium.