Ghana youth international Ransford Osei scored in Israel for Maccabi Haifa and Isaac Vorsah was present again for Hoffenheim in the Bundesliga.
Inter Milan earned a sweet victory at Genoa ahead of their titanic champions league clash with Manchester United at the Old Trafford.
Midfielder Sulley Ali Muntari came on as a substitute on 31st minute to replace Argentine international Nicolas Burdisso because of injury helping the Nerazzuri to extend their lead to 10 points.
At the Estadio Olimpico, Udinese caused a stir as they held AS Roma to a 1-1 draw.
In-form striker Kwadwo Asamoah enjoyed full time action for the Little Zebras.
Midfielder Ahmed Ampimah Barusso once again missed out of action as Siena shocked 13th placed Catania by 3 goals to nil.
Isaac Vorsah was in full time action for Hoffenheim as they drew goalless with giants Weder Bremen at the Rhein-Necker-Arena.
The villagers failed to reclaim top spot in the league.
Midfielder Derek Owusu Boateng sat on the substitute bench for FC Koln as they lost narrowly to Schalke 04 at away.
Bottom club Borussia Monchengbach humiliated Martin Jols Hamburg SV 4-1 at home.
Jerome Boateng played 85 minutes before being replaced by Mohammed Ndeng.
Godfred Aduobe was allowed a place on the Karlsruhe as they continue they abysmal run of form in the German Bundesliga.
Hans Adu-Sarpei was left out of the Leverkusen first team squad as they picked one point at home with Bochum.
In the Bundesliga II, Charles Takyi played in midfield for Spgvv Greuther Furth who bettered their chances of Bundesliga qualification with a 3-1 thrashing Oberhausen.
It was a great news for Chelsea fans and Ghanaians as the Bison marked a Blue return in top flight action over the weekend.
Chelsea brushed aside Coventry City to qualify for the semi-finals in the FA Cup.
Midfielder Michael Essien replaced Nigeria international John Obi Mikel on the 65th minute mark.
Champions Manchester United taught Fulham a bitter lesson at the Craven Cottage in their FA Cup tie.
Defender John Paintsil played 90 minutes and was booked on the 68th minute.
In the Coca-cola Championship, Quincy Owusu-Abeyie watched from the bench as his Cardiff City destroyed Doncaster Rovers by three goals to nil.
Charlton Athletic remained rooted to the bottom of the Championship league table after a lackluster display over the weekend at home.
Lloyd Sam left the pitch after things went out of hands for the Addicks.
In the League One, former Arsenal youngster Jo Osei Kuffuor secured a point for Bristol Rovers with a 90th minute strike.
Leaders Olympique Lyonnais hugely felt the absence of defender John Mensah as their back line was exposed by Lille. Lille won 2-0 Lyon.
Asamoah Gyan's Stade Rennes enforced a 2-0 home win over Moussa Narry's Auxerre for the maximum points.
Under 20 captain Andre Ayew was not part of the Lorient squad that lost at home to PSG.
Three Ghanaian players were in action as the Dutch Eredivisie continued over the weekend.
Heracles' Kwame Quansah and Emmanuel Boakye were not up to the task as their struggling club succumbed to a 1-0 defeat by De Graafschap.
Youngster Jeffrey Sarpong sat on the Ajax bench as they played out a one all draw game with Den Haag.
Eric Addo was dropped to the Roda JC over the weekend as they clashed with Francis Dickoh's FC Utrecht.
Whiles Addo was watching from the bench, Dickoh was enjoying full time action.
In the Egyptian Premier League, striker Ernest Papa Arko took his goal tally to 11 after he opened the scoring for El Geish through a spot kick on the 33rd munte.
Geish beat Ittihad 4-1.
National Under 20 goal poacher, Ransford Osei, announced his presence in the Israeli Premier League over the weekend with a goal that helped Maccabi Haifa claim all three points against Hapoel Tel Aviv.
In the Dennish League, FC Midjtylland were held 1-1 at home by Brondby.
Defender Kolja Afriyie lasted the entire duration of the game for Midtjylland.
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