The local Black Stars must pick themselves up and win against a sedulous Libyan side at the African Nations Championship Group B tie in Bouake to remain in the competition.
Head coach Milovan Rajevac has been experimenting during their training sessions the introduction of defenders Harrison Afful and Isaac Owusu could step in for Habib Mohammed and the suspended Ofosu Appiah.
The Serbain could revert to playing attackers upfront with a pair of Yaw Antwi and Kojo Poku.
Asante Kotoko's Jordan Opoku is also likely to play in the middle and Enoch Ebo Andoh can replace Rahim Ayew who was struggling with a stomach pain.
Ghana drew 2-2 with Zimbabwe despite an unimpressive display in that Group opener on Monday.
The Greens of Libya under head coach Faouzi Benzarti beat the Black Stars in September last year during the 2010 joint Nations Cup/World Cup qualifier.
In the other Group B match which will be played earlier a win for DR Congo would lead to their qualification into the next stage of the competition but a draw will keep the group wide open.