Bayern Munich could end the weekend 10 points off the top of the Bundesliga after dropping points against Freiburg.
Christian Gunter fired the mid-table hosts into a lead with a fine 20-yard strike.
Bayern thought they had turned it round through Mathys Tel's excellent curling effort and Jamal Musiala's placed shot after a solo run.
But Lucas Holer struck an 87th-minute volley to snatch a point for the hosts.
Bayern are now seven points behind unbeaten leaders Bayer Leverkusen, who visit Cologne in their game in hand on Sunday.
It could spell the end of the Munich outfit's decade of total dominance in German football. They have won a record 11 consecutive Bundesliga titles.
Their poor season has already led to the news Thomas Tuchel will leave his role as head coach at the end of the season.
If Bayern fail to beat Lazio on Tuesday in the Champions League last-16 second leg - they lost the first tie 1-0 in Rome - they are likely to end the season without any silverware.
It was a frustrating night for England striker Harry Kane, who missed several chances for Bayern and failed to build on his run of three goals in two games.
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