A man suspected to have killed his two children and seriously wounded his pregnant wife in a suburb of Kumasi is said to be on the run.
The incident which occurred at Sepe Timpom is said to have created panic in the area.
The children who are between the ages of 1 and 4 were found in a pool of blood in their room at about 9pm on Wednesday.
Eyewitness told Luv FM's Kwabena Ampratwum that the wife's intestines gushed out when she was stabbed in the abdomen. She was rushed to hospital.
Bodies of the children have been sent to the morgue for autopsy.