Ghana midfielder Afriyie Acquah was stretchered off in the second half against Uganda and will miss the team's next match.
The Black Stars are billed to face Bafana Bafana in an international friendly on Tuesday, but the Italy-based player has been confirmed as injured.
He picked up a knock in the 2018 World Cup qualifier against Uganda in Tamale on Friday which finished 0-0. It led to a sub by experienced Emmanuel Agyemang-Badu, which tactically altered the game.
The Ghana Football Association have not revealed the extent of his injury or confirmed the squad which will head to South Africa.
South Africa come into this friendly after drawing 1-1 with Burkina Faso on Saturday night. Bafana were just a couple of minutes from bagging the first away win of the group stage of African qualifying for the 2018 World Cup when their hosts leveled in Ouagadougou.
Story by Ghana/Joy Sports/Gary Al-Smith
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