Medeama SC will open their CAF Confederation Cup Group stage campaign at TP Mazembe on 17 June.
The Mauve and Yellows will be making their debut against last year's CAF Champions League winners who dropped out to play in the second-tier.
The Tarkwa-based will face the Ghana quintet who play for the Lubumbashi-based side.
Medeama's second Group match will be against MO Bejaia at home on 28 June and then travel to Young Africans for the final match to end the first round between 15-17 July.
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