Asante Kotoko will make a journey to Mpraeso to take on Storm Academy, whereas Hearts of conquerors Samartex will once again host another Ghana Premier League side, Liberty Professionals at Samreboi.
Another interesting pairing at this stage of the competition is GPL leaders All Stars against Mighty Royals at Wa
Matches will be played from Wednesday 11 May to Sunday 15 May, 2016.
Below is the full list of fixtures for the round of 16
Storm Academy Mpraeso vrs Asante Kotoko
Wa All Stars Vrs Mighty Royals
RTU vrs Bechem United
Wa Rockets vrs Asokwa Deportivo
Elmina Sharks vrs True Democracy
Okwahu United vrs Hasaacas
WAFA SC vrs Emmanuel FC
Samartax vrs Liberty Professionals
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