Medeama's opponent in the CAF Confederation Cup play-off will be revealed when the draw is made at CAF's headquarters in Cairo on Thursday.
The Ghanaians secured qualification after a riveting 2-0 aggregate win over Sudanese side Al Shendi.
The identity of the eight teams will be known after Wednesday round of CAF Champions League results.
However, the two-time Ghanaian FA Cup champions could face reigning African champions TP Mazembe who exited the competition after losing to Wydad Casablanca 3-1 on aggregate.
Malian side Stade de Malien, MO Béjaïa of Algeria, and Libyan side Al Ahli Tripoli are some of the possible teams the Ghanaian could face.
Medeama remain Ghana's surviving team in Africa inter-club competition this year.
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