Swansea City star Andre Dede Ayew will captain the Black Stars in the friendly against Canada in Washington on October 13.
Substantive captain Asamoah Gyan could not recover in time after sustaining a hamstring injury a few weeks ago.
Gyan 29, limped off during Shanghai SIPG's 3-0 defeat to Guangzhou Evergrande in the Chinese Super League when the game was only eighteen minutes old.
He has ruled himself out of the game as he will require not less than three weeks to recover fully from the injury.
Andre 25, captained the Black Stars in the game against Rwanda in Kigali and will be expected to take up the mantle once again following the withdrawal of the former Sunderland attacker.
The former Marseille winger has been in devastating form for Swansea City scoring 4 goals in 6 appearances in the English Premier League.
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