Major changes: South Africa coach Heyneke Meyer makes five changes for Wales Test

Tendai Mtawarira, Bismarck du Plessis, Willie le Roux, Cornal Hendricks and Lwazi Mvovo all return to the fold having not started the 22-6 victory in Italy last weekend.

The changes at the back were required, with Johan Goosen, Bryan Habana and JP Pietersen all returning to their clubs due to the fixture falling outside the Test window.

Mtawarira and Du Plessis come in for Adriaan Strauss and Trevor Nyakane, who drop to the bench, and Meyer is pleased with the current depth of his squad.

"This tour has been a good test of our depth and we're looking forward to see what the team can do on Saturday," he said. "We will face a fired-up Welsh side this weekend.

"They played very well against New Zealand [in a 34-16 defeat] and it will be a tough end to our season, but we want to finish on a high and the focus this week has been on ensuring we keep on building on what we've done thus far this year.

"All the players coming into the team have been part of our squad for most of the season.

"They know our plans and structures and now it's about execution on Saturday."

South Africa also confirmed scrum-half Rudy Paige would be sidelined for three to four weeks after picking up a medial knee ligament injury.

Team in full: Willie le Roux, Cornal Hendricks, Jan Serfontein, Jean de Villiers Lwazi Mvovo, Pat Lambie, Cobus Reinach, Duane Vermeulen, Teboho Mohoje, Marcell Coetzee, Victor Matfield, Eben Etzebeth, Coenie Oosthuizen, Bismarck du Plessis, Tendai Mtawarira.

Replacements: Adriaan Strauss, Trevor Nyakane, Julian Redelinghuys, Lood de Jager, Nizaam Carr, Francois Hougaard, Handre Pollard, Damian de Allende.