The defender made only his second start of the Premier League season at home to Liverpool on Sunday, a game which QPR went on to lose 3-2 in dramatic circumstances.
With the game goalless at half-time, Onuoha had to come off after picking up an injury, and the 27-year-old is now a doubt for the fixture with Villa at Loftus Road on Monday.
"I had a hamstring problem which happened about halfway through the first half," he told the club's official website.
"I tried to play on and it seemed ok but by the end of the half it got to the stage where I couldn't give 100 per cent for the team, so I had to come off.
"How serious is it? That depends how you define 'serious'! We'll just have to see how it goes between now and Monday."
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