The Black Queens dented their qualification chances to the semifinals of the African Women's Championships after going down in defeat to South Africa in Bata.
Veronica Phewa's 22nd minute strike puts the Banyana Banyana in the front seat for a place in the last four after opening their Group B campaign with a 1-0 victory over Tunisia.
Ghana failed to perform against the South Africans who struck the bar once as goalkeeper Memunatu Suleimana put in some good saves too.
The Black Queens can still qualify for the next stage of the competition depending on the outcome of the Nigeria v Tunisia game.
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